Establishing Your CBD Dosage
We always recommend you “start low, and go slow” as you establish your dose.
CBD is biphasic, meaning it can be energizing or sedating, depending on the amount consumed. In smaller doses, CBD can be energizing and mood enhancing. In larger doses, it can induce drowsiness. What is considered a small or large CBD dosage varies depending on how your body responds to cannabinoids, and your issues with pain, inflammation, or anxiety.
Establishing a recommended dose of cannabidiol (CBD) for a particular ailment is difficult for a variety reasons. Firstly, the bioavailability (the proportion of a substance to have an active effect when introduced into the body) of CBD varies, depending upon how it is administered. Meaning, if you were applying CBD topically verses taking it orally, the amount of CBD to enter your bloodstream would vary significantly. Listed below are the different means of administering CBD in order of highest to lowest bioavailability:
- Inhalation (vaporizer): Highest bioavailability, used to ease systemic pain, inflammation, anxiety, and stress. When inhaled, the cannabinoids and terpenes pass directly into the bloodstream from the lungs. Peak blood levels are achieved almost immediately, but do drop-off faster than other applications. We recommend inhalation for immediate relief, combined with either a sublingual or oral application to maintain relief. For details regarding our preloaded vaporizer kit, contact [email protected]
- Sublingual (drops/tinctures): Used to ease systemic pain, inflammation, anxiety, and stress. The cannabinoids and terpenes diffuse into the blood through connective tissue under the tongue. Absorption rate varies, depending on how your body metabolizes cannabinoids. Our sublingual drops include a minimum of 50mg/mL, available in our energizing Sativa or sedating Indica blend of terpenes. We also have sublinguals available for those suffering from Menstrual and Menopausal symptoms.
- Oral (gum, tablets, fruit chews): Used to ease systemic pain, inflammation, anxiety, and stress. Slower means of consuming cannabinoids and terpenes because the active ingredients must first pass through the gastrointestinal tract during digestion before entering the bloodstream. This can take up to 30-90min. The potency of the cannabinoids and terpenes are further minimized due to “first-pass metabolism” (the concentration of a drug is greatly reduced before it reaches systemic circulation) in the digestive tract. At Rx Remedies, we include proprietary plant extracts to our orally-consumed products to increase the bioavailability by up to 50%!
- Topical (balms/roll-ons/lotion): Used to treat localized pain and inflammation, delivering active ingredients to the bloodstream through the skin. Effects generally take 5-15min, and can last up to 12hrs. Our topicals include an additional plant-based remedies for both pain and inflammation, as well as known skin penetrants, allowing for greater absorption of our active ingredients.
The basis of comparison for all other means of administration is intravenously, which is assumed to have 100% bioavailability. We are not suggesting intravenous administration of our CBD products. Instead, we’re clarifying when studies reveal the bioavailability of CBD, it is by comparison to an intravenous application.
Secondly, how our bodies respond to cannabinoids effects how many milligrams one should consume, and how our bodies respond is based solely upon our endocannabinoid system. The endocannabinoid system (ECS) is responsible for a variety of biological functions, and can be found in each and every mammalian body. It naturally synthesizes the endocannabinoids our bodies produce, and can also be activated by phytocannabinoids, such as CBD and THC. The ECS also responds to terpenes, the pungent oils secreted by the cannabis plant. CBD and terpenes work synergistically together, meaning the therapeutic benefits of each are greatly intensified when combined. Your sensitivity (or lack-thereof) to CBD is based upon your body’s individual ECS, and its response to cannabinoids and terpenes. This is why how one responds to cannabis is different from one person to the next.
As an example, if three different people were to consume a strain of cannabis high in THC, you could potentially have three completely different reactions. One person could feel relaxed and at ease, one could feel anxious or paranoid, and the other could feel elated and energetic. Similarly, if three different people were to consume five drops of our sublingual drops (10mg of CBD), one could feel tired, one could feel energized, and the other could feel nothing at all. The first person may need to take less, as 10mg is too sedating. The second is probably taking the perfect dose, and the third requires a bit more.
Titration is the process of slowly increasing one medicine or liquid with another medicine or liquid. In regards of dosing CBD, it deals with taking small amounts of CBD until you’ve reached your own personal “magic number”.
For more information on CBD dosage, check out PubMed.gov, and ProjectCBD.org. If you have additional questions about our CBD products or need help selecting a product, contact us at [email protected]. We’re here to help!